Fibronectin is a 440-450 kDa glycoprotein composed of 2 sub-units of 220-250 kDa linked by a pair of C-terminal disulphide bonds. Fibronectin is present in plasma as a protein dimer (soluble) and in the extracellular matrix on cell surfaces as a polymer (heavy weight molecule).
The main function of fibronectin is to attach the cells to the extracellular matrix.
Fibronectin can be used as a culture supplement in a serum-free medium or as a fine coating.
Coated fibronectin brings about the adhesion and proliferation of BHK and CHO cells, endothelial cells, fibroblasts, smooth muscle cells, neurons, bronchial epithelial cells.
